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RMS Foundation
Bischmattstrasse 12
2544 Bettlach
Switzerland
Phone +41 32 644 2000
METHODS
Dissolution tests
(pH and ion release)
Many modern biomaterials interact with human tissue or even dissolve after they have fulfilled their function. One example is calcium phosphate ceramics, which are used for the repair of bone defects and as coatings on orthopedic implants. The resorption properties of such materials can be quantified using several standardized in vitro test methods. Samples are immersed in test solutions and pH changes, weight loss and/or ion release are measured.
According to which standards do we test?
Whenever possible, we carry out our testing services in accordance with or based on these international standards:
- ISO 13175-3
- ASTM F1926
- ISO 10993-14
Which devices do we use?
- Temperature-controlled incubator shaker IKA™ KS 4000i
- Agilent 7700x ICP-MS
- Polymer membrane Ca-ion selective electrode (Metrohm Titrando)
- pH electrodes
- Analytical balances
For which material tests do we use this method?
We use this method for the following material tests:
- Ca release and pH over 3 days in buffer solution (ISO 13175-3)
- Ca release and pH over 24 hours in buffer solution (ASTM F1926)
- Weight loss and ion release over 5 days (ISO 10993-14)
What you should know about this method?
What needs to be considered with these methods and samples?
We can test your samples as granules, powders or preforms.
For the ISO 10993-14 test, we need a sample quantity of 5 g per measurement. For tests according to ISO 13175-3 and ASTM F1926, sample quantities of less than 1 g are sufficient.
On request, we can also carry out parallel measurements on reference material (NIST).
Which products can be tested at the RMS?
We test all products. Contact us and we will discuss your individual requirements.
Are the RMS analyses accredited?
RMS is an ISO/IEC 17025 accredited analytical laboratory (accreditation type C). Many of the analyses, including the methods according to ISO 13175-3 and ASTM F1926, are already validated and accredited. New or customer-specific analysis methods can be validated and accredited by us.
Who is your contact person?
Christoph Stähli
Dr., MSc EPFL Mat. Sc.
Senior Scientist Bioceramics
+41 32 644 2044